Domain 1: The North American opioid crisis as a case study in multi-system regulatory failure
Domain 2: Opioids' dual nature as a benefit and a risk to health
Domain 3: Building integrated, well-supported, enduring systems for the care of substance use disorders
Domain 4: Maximizing the benefit and minimizing the adverse effects of criminal justice system involvement with people who are addicted to opioids
Domain 5: Creating healthy environments that can yield long-term declines in the incidence of addiction
Domain 6: Stimulating innovation in the response to addiction
Domain 7: Preventing opioid crises beyond North America
